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KMID : 0376419890130040269
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Chonbuk University Medical Journal
1989 Volume.13 No. 4 p.269 ~ p.276
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Effects of Enteropathogenic E. coli on the Histological and Histochemical Changes of the Lung
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Choi Sam-Im
Chun Young-Kyung
Kim Young-Sun
Kim Bog-Yi
Yoon Byoung-Taek
Kim Sang-Ho
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Abstract
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Bacterial endotoxin(lipopolysaccharide, LPS) induces pulmonary hypertension and edema, but the mechanism is not clearly known. So we have to study for this mechanism and morphological changes of the lung.
LPS was injected intravenously to mice with or without pretreatment with sheep erythrocytes. Twenty four hours after injection of LPS, histologic(HE stain) and histochemical (PAS, reticulin, and van Gieson stains) examinations for. the pulmonary tissue were done.
The results were as follows.
1. Histologically, LPS induced edema of interalveolar septa, infiltration of inflammatory cells such as segmented neutrophils, lymphocytes, and macrophages, especially around the vessels and small bronchial trees, and formation of granulomas in the lung. Occasionally, severe vasculitis was also noted.
2. These histological changes were more marked in the sheep erythrocyte-pretreated group, so completely occluded vessels with thrombi and cental necrosis of the granulomas were noted.
3. Histochemically, reticulin fibers were increased in amount in interalveolar septa and granuloma, and disruption of continuity of collagen fibers of blood vessels. was noted
These results suggest that LPS induces inflammatory reaction in the lung and pulmonary circulatory disturbance, especially it induces increase of the vascular permeability.
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KEYWORD
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bacterial endotoxin, pulmonary hypertenison, edwina
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